Advances in Human Genetics 9 by David G. Harnden, A. M. R. Taylor (auth.), Harry Harris,

By David G. Harnden, A. M. R. Taylor (auth.), Harry Harris, Kurt Hirschhorn (eds.)

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This can mean the description of virtually every cell examined. The question then must be asked as to what the value is of documenting in detail this enormous variability. If the variability really is quite random, obviously the detailed documentation is pointless, but we have not reached that stage yet. The number of cases of each tumor examined adequately is very small, and there is already evidence that the rearrangements observed are not random. l7l ,180,209,244 The great need now is for precise documentation of even small numbers of well-banded cells from well-documented cases.

Tumors that are radiation-induced occur frequently in treated retinoblastoma patients. 250 However, the mutation that predisposes to retinoblastoma also appears to give these patients an increased risk of osteosarcoma in sites other than irradiated areas. 135 Some pedigrees of retinoblastoma patients include relatives with sarcoma, but no retinoblastoma. 9l Increased tetraploidy has been shown to occur in cell cultures con- Chapter 1: Chromosomes and Neoplasia 19 taining epithelium (skin and colonic polyps) from Gardner syndrome patients.

Note, however, that this aberration can also occur in AML, and Engel et al. 54 have suggested that this aberration may be common to several types of malignant blood disorders. Acute Leukemia Acute Myeloid Leukemia Recent papers by Mitelman and Brandt,I79 Yamada and Furosawa,3IO Rowley and Potter,246 Oshimura et al. ,208 and Rowley245 have consolidated what is known about banded preparations in acute nonlymphocytic leukemias. Mark l71 concluded in his review that 53 certain cases from Rowley and Potter246 and Mitelman and Brandt I79 could be considered, consisting of 20 of 22 cases from Rowley's own series, of which 10 were 38 David G.

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