By Charles A. Schiffer (auth.), Anjali S. Advani, Hillard M. Lazarus (eds.)
The present explosion of latest parts of controversy within the remedy of acute lymphocytic leukemia in adults and teenagers makes this complete publication a far wanted reference for hematologists and oncologists. This ebook assembles top gurus from worldwide to hide the complete spectrum of ALL subtypes and their remedies. particular subject matters of dialogue comprise symptoms for allogeneic bone marrow transplant in first entire remission, the position of minimum residual illness in making remedy judgements, the therapy of teenagers, and the therapy of Philadelphia chromosome optimistic ALL with the appearance of the tyrosine kinase inhibitors. this can be the 1st booklet to concentration solely at the grownup ALL sufferer. It offers a whole evaluate of analysis, molecular pathogenesis, overview, and remedy for this crucial sufferer population.
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Extra info for Adult Acute Lymphocytic Leukemia: Biology and Treatment
A comprehensive genetic classification of adult acute lymphoblastic leukemia (ALL): Analysis of the GIMEMA 0496 protocol. Blood, 105(9), 3434–3441. 51. , et al. (1998). Deregulated expression of the TAL1 gene by t(1;5)(p32;31) in patient with T-cell acute lymphoblastic leukemia. Genes, Chromosomes & Cancer, 23(1), 36–43. 52. , et al. (2002). A single split-signal FISH probe set allows detection of TAL1 translocations as well as SIL-TAL1 fusion genes in a single test. Leukemia, 16(4), 755–761. 53.
The appearance of the leukemic blasts vary from small cells with coarsely reticular nuclear chromatin pattern, scant cytoplasm, and indistinct nucleoli to larger cells with finely dispersed nuclear chromatin, moderately abundant cytoplasm, and prominent nucleoli. Vacuoles might be present, but only rarely are they as prominent as in Burkitt lymphoma. Cytoplasmic granules are found in a small number of cases. Auer rods are absent. Morphologically, acute B-cell leukemia is indistinguishable from T-cell ALL.
Science, 270(5235), 467–470. 68. Alizadeh, A. , et al. (2000). Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature, 403(6769), 503–511. 69. Staudt, L. M. (2003). Molecular diagnosis of the hematologic cancers. The New England Journal of Medicine, 348(18), 1777–1785. 70. Armstrong, S. , et al. (2002). MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genetics, 30(1), 41–47. 71. Yeoh, E. , et al. (2002).